EDUCATION :

• 1997: Degree in Chemistry, University of Thessaloniki, Greece
• 2002-2003: Research at the laboratory of Dr. Sassone-Corsi, IGBMC, Strasbourg, France
• 2003: Ph.D. in Biochemistry, University of Thessaloniki, Greece
• 2005-2010: Post-doctoral fellow, Lab. of Biochemistry, Faculty of Medicine, University of Thessaly, Greece

RESEARCH INTERESTS & ACHIEVEMENTS:

• Investigation of regulation of the human Hypoxia Inducible Factor 1 (HIF-1)
• Investigation of regulation of lipid metabolism under hypoxia.
• Publication of 18 original research papers in peer-reviewed journals and 2 review articles (with total impact factor of 75, 391 citations and h-index: 12).

SELECTED PUBLICATIONS:

• Mylonis I, Sembongi H, Befani C, Liakos P, Siniossoglou S & Simos G (2012) Hypoxia causes triglyceride accumulation via HIF-1-mediated stimulation of lipin 1 expression. J Cell Sci 125, 3485-3493
• Mylonis I, Lakka A, Tsakalof A & Simos G (2010) The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions. Biochem Biophys Res Commun 398, 74-78.
• Kalousi A*, Mylonis I*, Politou AS, Chachami G, Paraskeva E & Simos G (2010) Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. J Cell Sci 123, 2976-2986. *Equal contribution
• Triantafyllou A*, Mylonis I*, Simos G, Bonanou S & Tsakalof A (2008) Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity. Free Radic Biol Med 44, 657-670. *Equal contribution
• Mylonis I, Chachami G, Paraskeva E & Simos G (2008) Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. J Biol Chem 283, 27620-27627.
• Mylonis I, Chachami G, Samiotaki M, Panayotou G, Paraskeva E, Kalousi A, Georgatsou E, Bonanou S & Simos G (2006) Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. J Biol Chem 281, 33095-33106.
• Mylonis I, Drosou V, Brancorsini S, Nikolakaki E, Sassone-Corsi P & Giannakouros T (2004) Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis. J Biol Chem 279, 11626-11631.
• Mylonis I & Giannakouros T (2003) Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1. Biochem Biophys Res Commun 301, 650-656.