Education:

• 1993, Diploma of Biology, Univ. of Thessaloniki, Greece
• 1997, Doktorat der Naturwissenschaften, European Molecular Biololgy Laboratory (EMBL)/University of Heidelberg, Germany
• 1997-2001, Post-doctoral research, Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Germany

Research interests & Achievements:

• Airway physiology
• Remodeling and contractile properties of Airway Smooth Muscle Cells
• Induction and activity of Hypoxia Inducible Factor (HIF)-1.
• Nucleocytoplasmic transport.
• Translational regulation and control of iron homeostasis by specific mRNA-protein interactions
• Publication of 32 original research papers in peer-reviewed journals, 1 review article and 2 letters to the editor (with total impact factor of 143, 909 citations and h-index: 15)

Selected publications:

• Paraskeva Ε, Atzberger Α, Hentze MW (1998). Α translational repression assay procedure (TRAP) for RNA-protein interactions in vivo. Proceedings of the National Academy of Sciences, USA 95, p. 951-956
• Paraskeva Ε, Gray ΝΚ, Schlager B,Wehr Κ, Hentze MW (1999). Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Μοlecular and Cellular Biology 19, p. 807-16
• Paraskeva Ε, Izaurralde Ε, Bischoff FR, Huber J, Kutay U, Hartmann Ε, Luhrmann R, Gorlich D (1999). CRM1-mediated Recycling of Snurportin 1 to the Cytoplasm. Journal of Cell Biology 145, p. 255-264
• Bohnsack MT, Reneger K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Gorlich D (2002). Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. The EMBO Journal 21, p. 6205-6215.
• Chachami G, Simos G, Hatziefthimiou A, Bonanou S, Molyvdas P-A, and Paraskeva E (2004). Cobalt Induces Hypoxia-Inducible Factor-1 a Expression in Airway Smooth Muscle Cells by a Reactive Oxygen Species– and PI3K-Dependent Mechanism American Journal of Respiratory Cell and Molecular Biology 31, p. 544–551.
• Papagianni M, Hatziefthimiou A, Chachami G, Gourgoulianis K, Molyvdas P-A and Paraskeva E (2007). Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in Airway Smooth Muscle cells. Experimental and Clinical Endocrinology & Diabetes 115, p.118-123.
• Chachami G, Hatziefthimiou A, Liakos P, Ioannou M, Koukoulis G, Bonanou S, Molyvdas P-A, Simos G, and Paraskeva E (2007). Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1α and airway responsiveness to ACh. American Journal of Physiology - Lung Cellular and Molecular Physiology 293, p. L913–L922.
• Mylonis Ι, Chachami G, Paraskeva E and Simos G (2008). Atypical CRM1-dependent Nuclear Export Signal Mediates Regulation of Hypoxia-inducible Factor-1α by MAPK. Journal of Biological Chemistry 283, p. 27620-27627.
• Chachami G, Paraskeva E, Mingot J, M., Braliou G, Görlich D and Simos G (2009). Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. Biochemical and Biophysical Research Communications 390(2), 235-40.
• Papadakis A, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G and A Koromilas (2010) eIF2α kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1α. Cancer Research 70, 7820.
• Tsapournioti S, Mylonis I, Hatziefhimiou A, Ioannou MG, Stamatiou S, Koukoulis GK, Simos G, Molyvdas P-A and Paraskeva E (2013). TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in Airway Smooth Muscle Cells. Journal of Cellular Physiology 228, p. 1745–1753.